GNE-431

Overview

GNE-431 is a potent, selective and noncovalent “pan- BTK ” inhibitor against C481R, T474I and T474Ms mutants. GNE-431 shows potency against wild-type BTK ( IC 50 = 3.2 nM) and potency against C481S mutant ( IC 50 = 2.5 nM). GNE-431 is proming for rasearch of haematological disorders and autoimmune diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Btk

Product Information

• Catalog No.: HY-124153
• CAS No.: 1433820-83-7
• Molecular Formula: C30H32N10O2
• Molecular Weight: 564.64
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source