T-3364366

Overview

T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase ( D5D ) inhibitor with IC 50 s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D ( IC 50 0=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC 50 =6200 nM) and delta-9 desaturase ( stearoyl-CoA desaturase , SCD, 50 >10000 nM) in the enzymatic activity assay.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Obesity | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Stearoyl-CoA Desaturase (SCD)

Product Information

• Catalog No.: HY-124346
• CAS No.: 1356354-09-0
• Molecular Formula: C18H16F3N3O3S2
• Molecular Weight: 443.46
• Purity: 99.80%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (4.69 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source