DBCO-NHCO-PEG4-amine

Overview

DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE ( HY-15162 ) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC 50 s of 280 nM and 22 nM in SKBR3 cells, respectively).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > ADC Linkers | Products > Signaling Pathways > PROTAC Linkers

Product Information

• Catalog No.: HY-124386
• CAS No.: 1255942-08-5
• Molecular Formula: C29H37N3O6
• Molecular Weight: 523.62
• Purity: 96.37%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source