12(R)-HETE

Overview

12(R)-HETE is a CYP -dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye, skin and liver. In the cornea, 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding, 12(R)-HETE indirectly activates AHR -mediated target gene transcription, while inhibiting the enzymatic activity of Na+,K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis, proangiogenesis, vasodilation, natriuresis, diuresis and intraocular pressure reduction, and can be widely used in studies related to psoriasis, inflammatory skin diseases and ocular inflammation.

Application

Products | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Psoriasis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Aryl Hydrocarbon Receptor | Products > Signaling Pathways > Na+/K+ ATPase | Products > Signaling Pathways > Prostaglandin Receptor

Product Information

• Catalog No.: HY-124404
• CAS No.: 82337-46-0
• Molecular Formula: C20H32O3
• Molecular Weight: 320.47
• Purity: 99.68%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source