Unguinol is a depsidone originally isolated from A. unguis. It is an inhibitor of pyruvate phosphate dikinase (PPDK; IC 50 =42.3 μM). It inhibits the growth of plants utilizing C4, but not C3, carbon fixation. Unguinol also inhibits the growth of the bacteria S. aureus and V. harveyi (GI 50 s=8.7 and 69.5 μM, respectively) and H460, MCF-7, and SF-268 cancer cells (GI 50 s=28.2, 50.8, and 44.3 μM, respectively).
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