MS-436

Overview

MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. Please contact us for GMP-grade inquiries.

Application

Products > PROTAC, Molecular glue > Inhibitors

Product Information

• Catalog No.: BP-23376
• CAS No.: 1395084-25-9
• Molecular Formula: C18H17N5O3S
• Molecular Weight: 383.4
• Purity: 98%
• Storage: -20°C
• Availability: In Stock

Source

Original product source