QL-X-138

Overview

QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK . QL-X-138 shows IC 50 s of 9.4 nM, 107.4 nM and 26 nM for BTK , MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti- dengue virus 2 activity, with an IC 50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Cancer | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Dengue Virus | Products > Signaling Pathways > Flavivirus | Products > Signaling Pathways > Btk | Products > Signaling Pathways > MNK

Product Information

• Catalog No.: HY-124645
• CAS No.: 1469988-63-3
• Molecular Formula: C25H19N5O2
• Molecular Weight: 421.45
• Purity: 98.17%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution
• Availability: In-stock

Source

Original product source