AF40431, the first reported small-molecule ligand of sortilin, has an IC 50 of 4.4 µM and a K d of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Neurotensin Receptor
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