CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor, with an IC 50 of 0.89 μM. CCT365623 hydrochloride suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF . CCT365623 hydrochloride is extremely well tolerated, and has good pharmacokinetic properties.
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