Thr101

Overview

Thr101 is an inhibitor ( IC 50 =2.9 μM) of phosphomannose isomerase ( PMI ).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Phosphomannose Isomerase (PMI) | Products > Signaling Pathways > Glucose-6-Phosphate Isomerase (GPI)

Product Information

• Catalog No.: HY-124890
• CAS No.: 727664-79-1
• Molecular Formula: C14H10FNOS
• Molecular Weight: 259.30
• Purity: 99.48%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 5 mg/mL (19.28 mM); Clear solution; Need ultrasonic and warming and heat to 160°C
• Availability: In-stock

Source

Original product source