Derquantel

Overview

Derquantel, a spirocyclic anthelmintic, is a competitive, orally active nicotinic acetylcholine receptor ( nAChR ) antagonist. Derquantel inhibits ACh-induced depolarization with an IC50 of 0.22 μM. By selectively antagonizing nAChRs on the somatic muscles of nematodes, Derquantel causes flaccid paralysis of muscles, thereby dislodging parasites from the host's gastrointestinal tract. Derquantel is applicable to research related to Haemonchus contortus infection and Ascaris suum infection .

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Infection | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > nAChR

Product Information

• Catalog No.: HY-125159
• CAS No.: 187865-22-1
• Molecular Formula: C28H37N3O4
• Molecular Weight: 479.61
• Purity: 98.4%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source