Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells ( EC 50 =1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells ( IC 50 =2.0 μg/mL for both).
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