Wiskostatin

Overview

Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein ( N-WASP )-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC 50 value of 20.7 μM and a potent inhibitor of clathrin-mediated endocytosis with an IC 50 value of 6.9 μM. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Arp2/3 Complex

Product Information

• Catalog No.: HY-12534
• CAS No.: 253449-04-6
• Molecular Formula: C17H18Br2N2O
• Molecular Weight: 426.15
• Purity: 99.87%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.87 mM); Clear solution
• Availability: In-stock

Source

Original product source