Roridin E

Overview

Roridin E is a glucose-6-phosphatase ( G6Pase ) inhibitor and antibiotic , and is a metabolic byproduct of Roridin A ( HY-N9599 ). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid ( HY-N0729 )) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase , and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A ( HY-107426 ) and Roridin A . Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies.

Application

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Product Information

• Catalog No.: HY-125539
• CAS No.: 16891-85-3
• Molecular Formula: C29H38O8
• Molecular Weight: 514.61
• Purity: 99.98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source