VRT-18858

Overview

VRT-18858 (RU-36384), the active metabolite of Pralnacasan ( HY-19676 ), is a potent interleukin-1β converting enzyme ( ICE ) inhibitor ( K i = 1.4 nM). VRT-18858 inhibits LPS ( HY-D1056 )-induced IL-1β release ( IC 50 = 0.42 µM) and S. aureus Cowan-induced IL-1β and IL-18 release ( IC 50 =1.3 and 2.1 µM, respectively) in human peripheral blood mononuclear cells. VRT-18858 can be used for osteoarthritis research.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Osteoarthritis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-125577
• CAS No.: 192756-07-3
• Molecular Formula: C24H25N5O7
• Molecular Weight: 495.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source