ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC 50 values of 7.12 nM, 517 nM for hS1P 1 and hS1P 3 , respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > LPL Receptor
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