(R)-KT109

Overview

(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC 50 values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ , respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α . (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > DAGL

Product Information

• Catalog No.: HY-126031
• CAS No.: 2055172-60-4
• Molecular Formula: C27H26N4O
• Molecular Weight: 422.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source