Tolcapone 3-β-D-glucuronide

Overview

Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone ( HY-17406 ) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC 50 of 773 nM. Tolcapone can inhibits α-syn and Aβ 42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease , such as Parkinson disease and neuroblastoma.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Others | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > COMT | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-126194
• CAS No.: 204853-33-8
• Molecular Formula: C20H19NO11
• Molecular Weight: 449.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source