PKC-theta inhibitor 1

Overview

PKC-theta inhibitor 1 is an orally active and selective ATP-competitive inhibitor of Protein Kinase Cθ ( PKCθ ), with a K i value of 6 nM. PKC-theta inhibitor 1 inhibits T-cell-mediated inflammatory responses by suppressing the release of proinflammatory cytokines ( IL-2 IC 50 = 0.21 μM in anti-CD3/CD28-stimulated PBMCs; IL-17 IC 50 = 1 μM in CD3/CD28-stimulated Th17 cells) PKC-theta inhibitor 1 significantly reduces symptoms in mice with ongoing experimental autoimmune encephalomyelitis (EAE). PKC-theta inhibitor 1 can be used for the study of T-cell-mediated inflammatory diseases such as multiple sclerosis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-126328
• CAS No.: 1160501-81-4
• Molecular Formula: C17H15F3N4O
• Molecular Weight: 348.32
• Purity: 99.45%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (3.59 mM); Clear solution
• Availability: In-stock

Source

Original product source