RO5256390

Overview

RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine ( HY-14541 ). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP ( HY-B2176 )-induced TNF secretion in mouse bone marrow-derived macrophages.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Depression | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Trace Amine-associated Receptor (TAAR)

Product Information

• Catalog No.: HY-12700
• CAS No.: 1043495-96-0
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.30
• Purity: 98.75%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution
• Availability: In-stock

Source

Original product source