Artecanin is a SARS-CoV-2 main protease (M pro ) inhibitor with predicted high gastrointestinal absorption and oral bioavailability, and no predicted hepatotoxicity, carcinogenicity, mutagenicity or cytotoxicity. Artecanin interacts with His41 and Cys145, the key amino acid residues in the active site of M pro , blocks the cleavage and maturation of viral precursor proteins, and forms a stable complex with M pro . Artecanin blocks the invasion of SARS-CoV-2 . Artecanin is applicable to the research of COVID-19.
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