Cycloguanil-d 4 (hydrochloride)

Overview

Cycloguanil-d 4 (Chlorguanide triazine-d 4 ) hydrochloride is the deuterium labeled Cycloguanil hydrochloride ( HY-12784A ). Cycloguanil hydrochloride is a dihydrofolate reductase ( DHFR ) inhibitor with an IC 50 of 10.8 μM against human DHFR . Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3 , thereby exhibiting anticancer activity.

Application

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Product Information

• Catalog No.: HY-12784AS
• CAS No.: 1189427-23-3
• Molecular Formula: C11H11D4Cl2N5
• Molecular Weight: 292.20
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source