mGluR7 antagonist-2 (compound 1) is a potent and selective metabotropic glutamate receptor 7 ( mGluR7 ) allosteric antagonist ( IC 50 = 20 nM). mGluR7 antagonist-2 shows high selectivity over other mGluRs ( mGluR1/2/3/4/5/6/8 ).
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