Diflapolin

Overview

Diflapolin is a highly active dual 5-lipoxygenase-activating protein ( FLAP ) /soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC 50 s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH ( IC 50 =20?nM).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > FLAP | Products > Signaling Pathways > Epoxide Hydrolase

Product Information

• Catalog No.: HY-128171
• CAS No.: 724453-98-9
• Molecular Formula: C22H17Cl2N3O2S
• Molecular Weight: 458.36
• Purity: 99.33%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2.08 mg/mL (4.54 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source