AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3) . AN3661 inhibits Plasmodium falciparum laboratory-adapted strains (mean IC 50 =32 nM), Ugandan field isolates (mean ex vivo IC 50 =64 nM), and murine P. berghei and P. falciparum infections.
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