PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC 50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED 50 of 15.18 μg/mL for T.brucei . The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively.
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