PROTAC CRBN Degrader-1

Overview

PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader that achieves a selective degradation of CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other . (Pink: Cereblon ligand ( HY-128846 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-128847 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-128845
• CAS No.: 2358775-70-7
• Molecular Formula: C53H72N8O13S
• Molecular Weight: 1061.25
• Purity: 98.77%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 5 mg/mL (4.71 mM); Clear solution
• Availability: In-stock

Source

Original product source