EN6

Overview

EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase . EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag , leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy . EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-128892
• CAS No.: 1808714-73-9
• Molecular Formula: C19H14F2N4O2
• Molecular Weight: 368.34
• Purity: 99.42%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 10 mg/mL (27.15 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source