NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λ ex : 470 nm, λ em : 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H 2 O 2 , ClO - , O 2 - ?, and ?OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis , and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma.
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