Paraherquamide A

Overview

Paraherquamide A (PNU-97333) is an anthelmintic and nicotinic acetylcholine receptor ( nAChR ) antagonist, with pIC 50 values ranging from 6.87 to 7.58 for L-type nAChR and from 4.84 to 5.54 for N-type nAChR . Paraherquamide A acts as a competitive antagonist against multiple nematode nAChR subtypes, as well as a mixed competitive-noncompetitive antagonist against nematode N-type nAChR . Paraherquamide A induces flaccid paralysis in parasitic nematodes without altering ATP levels, inhibits nematode motility, and antagonizes cholinergic agonist-induced muscle contraction in nematodes. Paraherquamide A can be used in studies related to nematode parasitic infections.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Infection | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > nAChR

Product Information

• Catalog No.: HY-129591
• CAS No.: 77392-58-6
• Molecular Formula: C28H35N3O5
• Molecular Weight: 493.59
• Purity: 99.58%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source