Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor ( K i =11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase ( eNOS ) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase ( IC 50 =3.7 μM) and blocks the production of melanin.
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