β-NF-JQ1

Overview

β-NF-JQ1 is a BRD2/3/4 PROTAC degrader. β-NF-JQ1 recruits the AhR E3 ligase complex to BRD2 , BRD3 and BRD4 , induces AhR- BRD interaction, and mediates AhR-dependent degradation through the proximity effect between the target protein and AhR. β-NF-JQ1 acts as an antiproliferative and cytotoxic agent that induces anticancer activity associated with BRD protein knockdown. β-NF-JQ1 can be used for research on breast cancer and neuroblastoma. (Pink: BRD4 and BRD2 and BRD3 ligand ( HY-78695 ); Blue: Aryl Hydrocarbon Receptor ligand ( HY-114740 ); Black: linker ( HY-176390 )).

Application

Products | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Aryl Hydrocarbon Receptor

Product Information

• Catalog No.: HY-130256
• CAS No.: 2380000-55-3
• Molecular Formula: C45H42ClN5O6S
• Molecular Weight: 816.36
• Purity: 98.05%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.06 mM); Clear solution
• Availability: In-stock

Source

Original product source