SB-773812 is a moderate-affinity antagonist at dopamine receptor 2 ( pKi =7.4) and a high-affinity antagonist at the dopamine receptor 3 ( pKi =8.5) and at the serotonin 5-hydroxytryptamine receptors 2A ( pKi =9.0), 2C ( pKi =8.1), and 6 ( pKi =8.1). SB-773812 is promising for research of central nervous system disorders.
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