Aβ42-IN-1, compound 1v, is a novel, potent and orally active? γ-secretase modulator (GSM) . Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 ?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > γ-secretase
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