N-piperidine Ibrutinib hydrochloride

Overview

N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 ( HY-133137 ). SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM.

Application

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Product Information

• Catalog No.: HY-130983
• CAS No.: 2231747-18-3
• Molecular Formula: C22H23ClN6O
• Molecular Weight: 422.91
• Purity: 98.06%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (5.91 mM); Clear solution
• Availability: In-stock

Source

Original product source