γ-Amanitin

Overview

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC 50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > ADC Payloads

Product Information

• Catalog No.: HY-131081
• CAS No.: 21150-23-2
• Molecular Formula: C39H54N10O13S
• Molecular Weight: 902.97
• Purity: 90.0%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 1.25 mg/mL (1.38 mM); Clear solution
• Availability: In-stock

Source

Original product source