SPDP-Val-Cit-PAB-PNP

Overview

SPDP-Val-Cit-PAB-PNP is a cleavable ADC linker featuring an SPDP group, a Val-Cit dipeptide, a para-aminobenzyl (PAB) spacer and a para-nitrophenyl (PNP) carbonate group. SPDP is a thiol-specific covalent linker which forms disulfide bonds with cysteine residues of proteins. Val-Cit-PAB is a protease-cleavable linker which is designed for efficient payload release upon proteolysis. Finally, PNP is a good leaving group which is activated towards nucleophilic attack such as from amines.

Application

Products > PEG Linkers > SPDP PEG | Products > ADC Linker, ADC Payload > Cleavable Linkers > Val-Cit | Products > PEG Linkers > SPDP PEG > SPDP Peptide

Product Information

• Catalog No.: BP-24353
• CAS No.: 159857-81-5
• Molecular Formula: C33H39N7O9S2
• Molecular Weight: 741.8
• Purity: 98%
• Storage: -20°C
• Solubility: DMSO, DCM, DMF
• Availability: In Stock

Source

Original product source