BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

Overview

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?( HY-131183 ). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC 50 of 39.2 nM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Target Protein Ligand-Linker Conjugates

Product Information

• Catalog No.: HY-131386A
• CAS No.: 2691796-83-3
• Molecular Formula: C41H45Cl3N4O5
• Molecular Weight: 780.18
• Purity: 95.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution
• Availability: In-stock

Source

Original product source