SJF-1528

Overview

SJF-1528 ( PROTAC 1) is a potent EGFR PROTAC degrader with DC 50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2 . SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research. (Pink: EGFR ligand ( HY-159047 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-130532 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-131864
• CAS No.: 2230821-38-0
• Molecular Formula: C55H57ClFN7O8S
• Molecular Weight: 1030.60
• Purity: 98.86%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source