JHU37152

Overview

JHU37152 is a potent and brain-penetrant DREADD agonist, with EC 50 s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [ 3 H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR

Product Information

• Catalog No.: HY-131891
• CAS No.: 2369979-67-7
• Molecular Formula: C19H20ClFN4
• Molecular Weight: 358.84
• Purity: 99.72%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (3.48 mM); Clear solution
• Availability: In-stock

Source

Original product source