Protein kinase inhibitor H-7

Overview

Protein kinase inhibitor H-7 is a selective inhibitor of PKC and cyclic nucleotide-dependent protein kinases, with a K i value of 6.0 μM for rabbit protein kinase C, a K i value of 3.0 μM for rabbit cAMP -dependent protein kinase, and a K i value of 5.8 μM for porcine cGMP -dependent protein kinase. Protein kinase inhibitor H-7 has no effect on Ca 2+ -calmodulin-dependent enzymes . Protein kinase inhibitor H-7 regulates the Actin cytoskeleton , inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Others | Products > Signaling Pathways > PKC | Products > Signaling Pathways > PKA | Products > Signaling Pathways > PKG | Products > Signaling Pathways > Arp2/3 Complex

Product Information

• Catalog No.: HY-131900
• CAS No.: 84477-87-2
• Molecular Formula: C14H17N3O2S
• Molecular Weight: 291.38
• Purity: 99.96%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source