3-Chlorodiphenylamine is a high affinity Ca 2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) ( K d =6 µM ). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca 2+ -sensitizing compounds due to its small size, and can be used for systolic heart failure research.
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