LASSBio-1135

Overview

LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC 50 = 18.5 μM). LASSBio-1135 reverts the Capsaicin ( HY-10448 )-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > TRP Channel

Product Information

• Catalog No.: HY-131986
• CAS No.: 852453-71-5
• Molecular Formula: C18H14N4
• Molecular Weight: 286.33
• Purity: 99.05%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 0.67 mg/mL (2.34 mM); Clear solution
• Availability: In-stock

Source

Original product source