Belnacasan

Overview

Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE) / caspase-1 with K i s of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC 50 of ~0.7 μM.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Depression | Products > Disease Areas > Pain | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-13205
• CAS No.: 273404-37-8
• Molecular Formula: C24H33ClN4O6
• Molecular Weight: 509.00
• Purity: 99.99%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.91 mM); Clear solution
• Availability: In-stock

Source

Original product source