ONX-0914

Overview

ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7) , the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (K i =5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Bacterial Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Proteasome | Products > Signaling Pathways > Bacterial | Products > Signaling Pathways > HIV

Product Information

• Catalog No.: HY-13207
• CAS No.: 960374-59-8
• Molecular Formula: C31H40N4O7
• Molecular Weight: 580.67
• Purity: 99.72%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.17 mg/mL (3.74 mM); Clear solution
• Availability: In-stock

Source

Original product source