DSM705 hydrochloride

Overview

DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites ( IC 50 =95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Dihydroorotate Dehydrogenase | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-132171A
• CAS No.: 2989908-08-7
• Molecular Formula: C19H20ClF3N6O
• Molecular Weight: 440.85
• Purity: 98.22%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution
• Availability: In-stock

Source

Original product source