ZXH-4-137

Overview

ZXH-4-137 is a CRBN PROTAC degrader. ZXH-4-137 brings CRBN and VHL E3 ligase into proximity, induces CRBN ubiquitination and proteasomal degradation, and exhibits high selectivity for CRBN . ZXH-4-137 blocks the degradation of CRBN-dependent target proteins such as GSPT1 and CDK9 . ZXH-4-137 serves as a chemical knockdown tool compound for investigating CRBN -dependent biological processes. (Pink: Cereblon ligand ( HY-103596 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-132859 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-132862
• CAS No.: 2711006-74-3
• Molecular Formula: C47H60N6O9S
• Molecular Weight: 885.08
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source