VHL Ligand 8

Overview

VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 ( HY-133020 ), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 nM.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Ligands for E3 Ligase

Product Information

• Catalog No.: HY-133045
• CAS No.: 2701565-76-4
• Molecular Formula: C23H29N3O6
• Molecular Weight: 443.49
• Purity: 98.10%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution
• Availability: In-stock

Source

Original product source