4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 ( CYP2D6 ). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor ( K i values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
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