DBCO-PEG4-Val-Cit-PAB-MMAE

Overview

DBCO-PEG4-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a hydrophilic PEG spacer, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups on a target molecule to form stable triazole linkages, while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB structure.

Application

Products > PEG Linkers > GGFG Linkers | Products > ADC Linker, ADC Payload > Cleavable Linkers > Val-Cit-MMAE | Products > ADC Linker, ADC Payload > ADC Payload > MMAE | Products > Click Chemistry Reagents > DBCO > DBCO-PEG-peptide

Product Information

• Catalog No.: BP-25659
• CAS No.: 2129164-91-4
• Molecular Formula: C88H128N12O19
• Molecular Weight: 1658.1
• Purity: 98%
• Storage: -20°C
• Solubility: DMSO, DCM, DMF
• Availability: In Stock

Source

Original product source